Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent
نویسندگان
چکیده
منابع مشابه
1-Benzyl-N-methyl-1H-pyrrole-2-carboxamide
The asymmetric unit of the title compound, C(13)H(14)N(2)O, contains two independent mol-ecules, which differ in the twist of the phenyl ring: the N(pyrrole)-C(H(2))-C-C torsion angles are -73.0 (3) and 17.1 (3)°. In the crystal structure, mol-ecules are linked through N-H⋯O hydrogen bonds into chains extending along the a axis.
متن کامل(S)-N-Benzyl-2-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
The structure of the title compound, C(18)H(20)N(2)O, at 173 K has hexa-gonal (P6(1)) symmetry. The N-containing six-membered ring assumes a half-chair conformation. In the crystal, inter-molecular N-H⋯O hydrogen bonding via the amide groups cross-link the mol-ecules along the a axis. The absolute configuration was confirmed by 2D NMR studies.
متن کامل(S)-2-Benzyl-N-(2,6-diisopropylphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
The asymmetric unit of the title compound, C(29)H(34)N(2)O, contains two mol-ecules in which the N-containing six-membered rings assume different conformations viz. half-chair and envelope. Inter-molecular N-H⋯O hydrogen bonding via the amide groups cross-link the mol-ecules in the crystal structure.
متن کامل(S)-5-Oxo-N-phenylpyrrolidine-2-carboxamide
The title compound, C(11)H(12)N(2)O(2), shows an S configuration, in which the pyrrolidinone ring is twisted with respect to the phenyl plane, making a dihedral angle of 70.73 (7)°. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds, building up a layer parallel to (001).
متن کاملSynthesis, Evaluation and Qsar Analysis of 5-nitrofuran-2-yl/4-nitrophenyl Methylene Substituted Hydrazides as Antitubercular Agents
A series of novel N'-((5-nitrofuran-2-yl/4-nitrophenyl) methylene) substituted hydrazides (3a-3i & 4a-4i) was synthesized, and tested for in vitro antimycobacterial activity, and their quantitative structure activity relationship (QSAR) of hydrazide derivatives is reported here. The results of anti-mycobacterial activity study indicated that the presence of halogen substitution at benzohydrazid...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2019
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2018.12.053